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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC6A4 All Species: 36.06
Human Site: S277 Identified Species: 72.12
UniProt: P31645 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P31645 NP_001036.1 630 70325 S277 I W K G V K T S G K V V W V T
Chimpanzee Pan troglodytes XP_001135066 630 70262 S277 I W K G V K T S G K V V W V T
Rhesus Macaque Macaca mulatta Q9MYX0 630 70239 S277 I W K G V K T S G K V V W V T
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q60857 630 70129 S277 I W K G V K T S G K V V W V T
Rat Rattus norvegicus P31652 630 70153 S277 I W K G V K T S G K V V W V T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508462 865 94609 S507 L W K G V K T S G K V V W I T
Chicken Gallus gallus NP_998737 670 74409 S317 I W K G V K T S G K V V W V T
Frog Xenopus laevis A7Y2W8 633 71004 A287 H A M V W G D A A S Q I F Y S
Zebra Danio Brachydanio rerio NP_001035061 646 72103 S290 I W K G V K T S G K V V W V T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P51905 622 69307 V272 G V R S A G K V V W V T A L A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q03614 615 69247 I275 V V L G I L F I R G V T L P G
Sea Urchin Strong. purpuratus XP_001204030 641 70931 S286 I W K G I K A S G K V V W V T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 98.5 N.A. N.A. 92.8 91.7 N.A. 38.1 77.6 42.1 68.5 N.A. 50.4 N.A. 43.6 49.4
Protein Similarity: 100 99.5 99.5 N.A. N.A. 95.5 94.9 N.A. 52.9 85.2 60.8 80.6 N.A. 66.9 N.A. 63.3 66.6
P-Site Identity: 100 100 100 N.A. N.A. 100 100 N.A. 86.6 100 0 100 N.A. 6.6 N.A. 13.3 86.6
P-Site Similarity: 100 100 100 N.A. N.A. 100 100 N.A. 100 100 26.6 100 N.A. 20 N.A. 26.6 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 0 9 0 9 9 9 0 0 0 9 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 9 0 0 0 0 0 9 0 0 % F
% Gly: 9 0 0 84 0 17 0 0 75 9 0 0 0 0 9 % G
% His: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 67 0 0 0 17 0 0 9 0 0 0 9 0 9 0 % I
% Lys: 0 0 75 0 0 75 9 0 0 75 0 0 0 0 0 % K
% Leu: 9 0 9 0 0 9 0 0 0 0 0 0 9 9 0 % L
% Met: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % Q
% Arg: 0 0 9 0 0 0 0 0 9 0 0 0 0 0 0 % R
% Ser: 0 0 0 9 0 0 0 75 0 9 0 0 0 0 9 % S
% Thr: 0 0 0 0 0 0 67 0 0 0 0 17 0 0 75 % T
% Val: 9 17 0 9 67 0 0 9 9 0 92 75 0 67 0 % V
% Trp: 0 75 0 0 9 0 0 0 0 9 0 0 75 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _